
The answer is MINUS eight pi alpha.
The Big Bang Theory Season 1, Episode 13

A hydrogen atom, H,
plus pigs MINUS P, "higs."
The Big Bang Theory Season 3, Episode 13

...MINUS 21 men
before the loss of virginity...
The Big Bang Theory Season 4, Episode 1

We add a plus douche bag
to a MINUS douche bag
Breaking Bad Season 4, Episode 8

MINUS my fee,
which is 17 percent,
Breaking Bad Season 2, Episode 9